Leflunomide-d4

CAS: 1189987-23-2

Ref. TR-L322752

Product Information

• Name: Leflunomide-d4
• Synonyms: 5-Methyl-N-[2,3,5,6-tetradeuterio-4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide, 5-Methyl-N-[4-(trifluoromethyl)phenyl-2,3,5,6-d4]-4-isoxazolecarboxamide, Leflunomide-D4 (phenyl-D4)
• Brand: TRC
• Description: Applications An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases.This compound is suitable for dihydroorotate dehydrogenase (DHODH) related research. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Vrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009),

Chemical properties

• Molecular weight: 274.23
• Formula: C₁₂D₄H₅F₃N₂O₂
• Color/Form: Neat
• InChI: InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)/i2D,3D,4D,5D
• InChI key: InChIKey=VHOGYURTWQBHIL-QFFDRWTDSA-N
• SMILES: [2H]c1c([2H])c(C(F)(F)F)c([2H])c([2H])c1NC(=O)c1cnoc1C