Estimated delivery in United States, on Wednesday 26 Jun 2024
Product Information
Name:
Linaclotide-d4
Synonyms:
- L-Cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-d4-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine Cyclic (1→6),(2→10),(5→13)-Tris(disulfide)
- 11: PN: WO2008151257 SEQID: 55 claimed protein-d4
- 13: PN: WO2008151257 SEQID: 57 Claimed Protein-d4
- 2074: PN: US20090062207 SEQID: 3 Claimed Protein-d4
- 40: PN: WO2010065751 SEQID: 55 Claimed Protein-d4
- 42: PN: WO2010065751 SEQID: 57 claimed protein-d4
- 55: PN: US20100152118 SEQID: 55 Claimed Protein-d4
- 55: PN: WO2011069038 SEQID: 55 Claimed Sequence-d4
- 55: PN: WO2012037380 SEQID: 55 Unclaimed Protein-d4
- 57: PN: WO2011069038 SEQID: 57 Claimed Sequence-d4
- See more synonyms
- 57: PN: WO2012037380 SEQID: 57 Claimed Protein-d4
CAS:
Description:
Applications Linaclotide-d4 is the labeled analogue of a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
References Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
1530.76
Formula:
C59H75D4N15O21S6
Color/Form:
White to Off-White Solid
InChI:
InChI=1S/C59H79N15O21S6/c1-26-47(82)69-41-25-101-99-22-38-52(87)65-33(13-14-45(80)81)49(84)66-34(16-28-5-9-30(76)10-6-28)50(85)71-40(54(89)72-39(23-97-96-20-32(60)48(83)70-38)53(88)67-35(18-43(61)78)58(93)74-15-3-4-42(74)56(91)63-26)24-100-98-21-37(64-44(79)19-62-57(92)46(27(2)75)73-55(41)90)51(86)68-36(59(94)95)17-29-7-11-31(77)12-8-29/h5-12,26-27,32-42,46,75-77H,3-4,13-25,60H2,1-2H3,(H2,61,78)(H,62,92)(H,63,91)(H,64,79)(H,65,87)(H,66,84)(H,67,88)(H,68,86)(H,69,82)(H,70,83)(H,71,85)(H,72,89)(H,73,90)(H,80,81)(H,94,95)/t26-,27+,32-,33+,34+,35-,36-,37-,38-,39+,40-,41-,42-,46-/m0/s1/i1D3,26D
InChI key:
InChIKey=KXGCNMMJRFDFNR-UIVXFAJJSA-N
SMILES:
[2H]C([2H])([2H])[C@]1([2H])NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H]2CSSC[C@H](N)C(=O)N[C@H]3CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)CSSC[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC3=O)C(=O)N2
MDL:
Melting point:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-L465882 Linaclotide-d4
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