trans-Loperamide N-Oxide

CAS: 106900-12-3

Ref. TR-L469460

Product Information

• Name: trans-Loperamide N-Oxide
• Synonyms: Loperamide Hydrochloride Imp. F (EP), Loperamide Imp. F (EP), Loperamide USP Related Compound F, Loperamide USP RC F, Loperamide Oxide, trans-4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutanamide 1-oxide, Arestal, Loperamide oxide, R 58425, Loperamide Related Compound F, Loperamide Hydrochloride Impurity F, Loperamide Impurity F, 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, 1-oxide, (E)-, 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-, 1-oxide, trans-, 4-[4-(4-chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide, Loperamide N-oxide, Loperamide oxide [INN:BAN], Loperamide oxyde, Loperamide oxyde [French], Loperamidum oxidum, Loperamidum oxidum [Latin], Oxido de loperamida, Oxido de loperamida [Spanish], trans-4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutyramide 1-oxide, trans-N-Oxide of loperamide

Description

Stability Hygroscopic
Applications Loperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lavrijsen, K., et al.: Drug Metab. Dispos., 23, 354 (1995), Hesselink, D., et al.: Clin. Pharmacol. Ther., 74, 245 (2003), Hooijberg, J., et al.: Biochem. Pharmacol., 67, 1541 (2004),

• Brand: TRC

Chemical properties

• Molecular weight: 493.04
• Formula: C₂₉H₃₃ClN₂O₃
• Color/Form: Off-White
• InChI: InChI=1S/C29H33ClN2O3/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32(35)20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3/t28-,32-
• InChI key: InChIKey=KXVSBTJVTUVNPM-UHFFFAOYSA-N
• SMILES: CN(C)C(=O)C(CC[N+]1([O-])CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1