Product Information
- 5,7-Dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
- 5,7-Dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one
- 8-Prenylgenistein
- 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-
- 4H-1-benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-
- 5,7,4'-Trihydroxy-8-(3,3-dimethylallyl)isoflavone
Applications Lupiwighteone is a natural product derivative of Genistein (G350000). Genistein exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol.
References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987); O'Dell, T.J., et al.: Nature, 353, 588 (1991); Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992); Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992); Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992); Uckun, F.M., et al.: Science, 267, 886 (1995); Merck Index 12th ed. 4395, Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)
Chemical properties
Technical inquiry about: TR-L478020 Lupiwighteone
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