Mesna

CAS: 19767-45-4

Ref. TR-M225750

Product Information

• Name: Mesna
• Synonyms: Sodium 2-sulfanylethanesulfonate, 2-Mercapto-1-ethanesulfonic acid monosodium salt, 2-Mercaptoethanesulfonic acid monosodium salt, 2-Mercaptoethanesulfonic acid sodium salt, 2-Mercaptoethanesulphonicacid,sodiumsalt, D 7093, Ethanesulfonic Acid, 2-Mercapto-, Sodium Salt (1:1), Ethanesulfonic acid, 2-mercapto-, monosodium salt, Mesnex, Mesnum, Mistabron, Mistabronco, Mitexan, Mucofluid, Prehepon, Sodium 2-Sulfanylethanesulfonate, Ucb 3983, Uromitexan, Sodium 2-mercaptoethanesulfonate

Description

Applications Mesna reacts with acrolein and other urotoxic metabolites of oxazaphosphorines (cyclophosphamide or ifosfamide) to form stable, non-urotoxic compounds. Mesna does not have any antitumour activity, nor does it appear to interfere with the antitumour activity of antineoplastic drugs. This medication is used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.
References Tekeres, M., et al.: Clin. Ther., 4, 56 (1981), Brock, N., et al.: Eur. J. Cancer Clin Oncol., 18, 1377 (1982), James, C.A., et al.: Br. J. Clin. Pharmacol., 23, 561 (1987), Schoenike, S.E., et al.: Clin. Pharm., 9, 179 (1990),

• Brand: TRC

Chemical properties

• Molecular weight: 164.18
• Formula: C₂H₅O₃S₂·Na
• Color/Form: Neat
• InChI: InChI=1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1
• SMILES: O=S(=O)([O-])CCS.[Na+]