Metformin Hydrochloride

CAS: 1115-70-4

Ref. TR-M258815

Product Information

• Name: Metformin Hydrochloride
• Synonyms: Imidodicarbonimidic diamide, N,N-dimethyl-, hydrochloride (1:1), Biguanide, 1,1-dimethyl-, hydrochloride (6CI), Biguanide, 1,1-dimethyl-, monohydrochloride (8CI), Imidodicarbonimidic diamide, N,N-dimethyl-, monohydrochloride (9CI), 1,1-Dimethylbiguanide hydrochloride, Apo-Metformin, Apophage, Benofomin, Brot, Dabex, Denkaform, Dextin, Diabefagos, Diabetmim, Diabetmin, Diabetosan, Diabex, Diaformin, Dialon, Diformin, Diformin Retard, Dimefor, FORTAMET, Fornidd, Geamet, Glifage, Glucaminol, Glucofago, Glucoform, Glucoformin, Glucomet, Glucomin, Glucomine, Gluconil, Glucophage, Glucophage 850, Glucophage Forte, Glucophage Retard, Glucophage SR, Glucophage XR, Glucophage-Mite, Gludepatic, Glufor, Gluformin, Glumeformin, Glumetza, Glumin, Glumin XR, Glupermin, Glyceriphage, Glyciphage, Glycon, Glyformin, LA 6023, Meguan, Melbin, Metforal, Metgluco, Metomin, Miformin, N,N-Dimethylbiguanide hydrochloride, N,N-Dimethylbiguanidine monohydrochloride, N,N-Dimethylbiguanidinium chloride, N1,N1-Dimethylbiguanide hydrochloride, Neodipa, Orabet, Riomet, Siamformet, Walaphage, 1,1-Dimethylbiguanide hydrochloride, SKF-7407-A, Rosiglitazone related, 1,1-Dimethylbiguanide Hydrochloride, 3-(Diaminomethylidene)-1,1-Dimethylguanidine Hydrochloride (1:1), Biguanide, 1,1-dimethyl-, hydrochloride, Biguanide, 1,1-dimethyl-, monohydrochloride, Fortamet, Imidodicarbonimidic diamide, N,N-dimethyl-, hydrochloride (1:1), Imidodicarbonimidic diamide, N,N-dimethyl-, monohydrochloride, La 6023, N¹,N¹-Dimethylbiguanide hydrochloride, Obimat-SR

Description

Applications An oral hypoglycemic agent. Slows electron transport in the oxidation pathway in mitochondria. Has been reported to reverse Lupus symptoms in mice in conjunction with 2-deoxy-d-glucose (D239000). Metformin is a well-known type 2 diabetes treatment. Research shows that metformin may inhibit tumor growth both directly and indirectly. Studies indicate that metformin modulates the biology of aging. Metformin blocks the conversion of select substrates into glucose in a redox-dependent manner.
References Tucker, G.T., et al.: Brit. J. Clin. Pharmacol., 12, 235 (1981), DeFronzo, R.A., et al.: N. Engl. J. Med., 333, 541 (1995); Chem. and Eng. News, page 7, Feb. 23 (2015); Nir Barzilai et al., Cell Metabolism 23: 1060 June 14 (2016); Chem. and Eng. News, page 7, Feb. 23 (2015); Chem. and Eng. News, page 12, July 30 (2018)

• Brand: TRC

Chemical properties

• Molecular weight: 165.62
• Formula: C₄H₁₁N₅·ClH
• Color/Form: White
• InChI: InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
• InChI key: InChIKey=OETHQSJEHLVLGH-UHFFFAOYSA-N
• SMILES: CN(C)C(=N)NC(=N)N.Cl