D-Methionine-d4

CAS: 348-67-4

Ref. TR-M260552

Product Information

• Name: D-Methionine-d4
• Synonyms: (R)-Methionine-d4, MRX 1024-d4, NSC 45689-d4, S-Methyl-D-homocysteine-d4, (2R)-2-Amino-4-methylsulfanylbutanoic acid, (R)-2-Amino-4-(Methylmercapto)Butyric Acid, (R)-2-Amino-4-(methylthio)butanoic acid, (R)-Methionine, <span class="text-smallcaps">D</span>-Methionine, D-2-Amino-4-(Methylthio)Butyric Acid, D-Methionin, D-metionina, H-D-Met-OH, Methionine, <span class="text-smallcaps">D</span>-, Methionine, D-, Mrx 1024, Nsc 45689, S-Methyl-<span class="text-smallcaps">D</span>-homocysteine, S-Methyl-D-homocysteine

Description

Applications D-Methionine-d4 is labelled D-Methionine (M260550), an isomer of L-Methionine (M260440) which is a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).
References Campbell, K., et al.: Hear. Res., 92, 103 (2007); Cloven, N., et al.: Antican. Res., 20.6B, 4205 (1999); Vuyyuri, S., et al.: Clin. Cancer Res., 14, 2161 (2008)

• Brand: TRC

Chemical properties

• Molecular weight: 153.24
• Formula: C₅H₇D₄NO₂S
• Color/Form: Neat
• InChI: InChI=1S/C25H24FNO5S/c1-30-19-7-8-21-17(12-19)10-11-27-15-22-16(13-23(21)27)6-9-24(31-2)25(22)32-33(28,29)20-5-3-4-18(26)14-20/h3-9,12,14,23H,10-11,13,15H2,1-2H3
• InChI key: InChIKey=SIAVJTYUIMDRNA-UHFFFAOYSA-N
• SMILES: COc1ccc2c(c1)CCN1Cc3c(ccc(OC)c3OS(=O)(=O)c3cccc(F)c3)CC21