Product Information
Name:5-Methoxyindole-3-acetonitrile-d2
Controlled Product
Synonyms:
- 5-Methoxy-1H-indole-3-acetonitrile-d2
- (5-Methoxy-1H-indol-3-yl)acetonitrile-d2
- 3-(Cyanomethyl)-5-methoxyindole-d2
Brand:TRC
Description:Applications 5-Methoxyindole-3-acetonitrile-d2 is a labelled analogue of 5-Methoxyindole-3-acetonitrile (M262818), which is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors. 5-Methoxyindole-3-acetonitrile-d2 is also an intermediate in synthesizing Melatonin-d4 (M215002), a hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen reReferences Barchas, et al.: Nature, 214, 919 (1967); Glass, J.D., et al.: Science, 214, 821 (1981)
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Chemical properties
Molecular weight:188.222
Formula:C11D2H8N2O
Color/Form:Neat
InChI:InChI=1S/C11H10N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4H2,1H3/i4D2
SMILES:[2H]C([2H])(C#N)c1c[nH]c2ccc(OC)cc12
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