6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid-d5

CAS: 851884-87-2

Ref. TR-M264217

Product Information

• Name: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid-d5
• Synonyms: GKA 50-d5

Description

Applications 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid-d5 is the labeled analogue of (M264215), which is one of the glucokinase activator derivatives. GKAs activate GK via binding to an allosteric site of the enzyme. They increase glucose-stimulated insulin secretion and decrease blood glucose levels. Also, glucokinase activator GKA50 is shown to be able to promote proliferation by increasing the cell volume and thus, preventing apoptosis in rat pancreatic insulinoma-1 beta cell.
References Wei, P., et al.: Diabetologia, 52, 2142 (2009); McGlasson, L., et al.: Mol. Cell. Endo., 342, 48, (2011);

• Brand: TRC

Chemical properties

• Molecular weight: 469.541
• Formula: C₂₆D₅H₂₃N₂O₆
• Color/Form: Neat
• InChI: InChI=1S/C26H28N2O6/c1-17(11-19-7-5-4-6-8-19)33-22-12-21(13-23(14-22)34-18(2)16-32-3)25(29)28-24-10-9-20(15-27-24)26(30)31/h4-10,12-15,17-18H,11,16H2,1-3H3,(H,30,31)(H,27,28,29)/t17-,18-/m0/s1/i4D,5D,6D,7D,8D
• InChI key: InChIKey=OCBMECSFDVUYQN-SFJRSVAYSA-N
• SMILES: [2H]c1c([2H])c([2H])c(C[C@H](C)Oc2cc(O[C@@H](C)COC)cc(C(=O)Nc3ccc(C(=O)O)cn3)c2)c([2H])c1[2H]