2-[1-Methoxy-2-(1-naphthalenyl)ethylidene]propanedinitrile

CAS: 221243-13-6

Ref. TR-M265600

Product Information

• Name: 2-[1-Methoxy-2-(1-naphthalenyl)ethylidene]propanedinitrile
• Synonyms: [1-Methoxy-2-(1-naphthalenyl)ethylidene]propanedinitrile
• Brand: TRC
• Description: Applications 2-[1-Methoxy-2-(1-naphthalenyl)ethylidene]propanedinitrile is an intermediate used in the synthesis of 4-Amino-1-tert-butyl-3-(1’-naphthylmethyl)pyrazolo[3,4-d]pyrimidine (A603003), which is a highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase.References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999), Davies, S., et al.: Biochem. J., 351, 95 (2000), Regan, J., et al.: J. Med. Chem., 45, 2994 (2002), Bain, J., et al.: Biochem. J., 371, 199 (2003), Kuma, Y., et al.: J. Biol. Chem., 280, 19472 (2005)

Chemical properties

• Molecular weight: 248.28
• Formula: C₁₆H₁₂N₂O
• Color/Form: Neat
• InChI: InChI=1S/C16H12N2O/c1-19-16(14(10-17)11-18)9-13-7-4-6-12-5-2-3-8-15(12)13/h2-8H,9H2,1H3
• SMILES: COC(Cc1cccc2ccccc12)=C(C#N)C#N