Methyl 4-Fluoro-2-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzoate

Ref. TR-M268025

Product Information

• Name: Methyl 4-Fluoro-2-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzoate
• Synonyms: Methyl 2-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-4-fluorobenzoate
• Brand: TRC

Description

Applications Methyl 4-Fluoro-2-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzoate is a derivative of Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate (M265625(P)), which is the intermediate for ABT 199 (A112430(P)). ABT 199 is a potent and selective BCL-2 inhibitor that achieves potent antitumor activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
References Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013)

Chemical properties

• Molecular weight: 286.258
• Formula: C₁₅H₁₁FN₂O₃
• Color/Form: Neat
• InChI: InChI=1S/C15H11FN2O3/c1-20-15(19)11-3-2-9(16)8-13(11)21-12-5-7-18-14-10(12)4-6-17-14/h2-8H,1H3,(H,17,18)
• InChI key: InChIKey=YVXPHQBMYFDGGZ-UHFFFAOYSA-N
• SMILES: COC(=O)c1ccc(F)cc1Oc1ccnc2[nH]ccc12