N-Methyl Naltrexone Bromide

CAS: 73232-52-7

Ref. TR-M320350

Product Information

• Name: N-Methyl Naltrexone Bromide
• Synonyms: Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, bromide (1:1), (5α)-, MRZ 2663BR, Methylnaltrexone bromide, N-Cyclopropylmethyl-noroxymorphone methobromide, N-Methylnaltrexone bromide, Naltrexone methobromide, Naltrexone methyl bromide, Relistor
• Brand: TRC
• Description: Stability HygroscopicApplications A metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX; M320350), a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone (M320350) is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)

Chemical properties

• Molecular weight: 436.35
• Formula: C₂₁H₂₆BrNO₄
• Color/Form: Neat
• InChI: InChI=1S/C21H25NO4.BrH/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13;/h4-5,12,16,19,25H,2-3,6-11H2,1H3;1H/t16-,19+,20+,21+,22?;/m1./s1
• SMILES: Br.C[N+]1(CC2CC2)CC[C@]23c4c5ccc([O-])c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5