Methyl 4-Methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate

CAS: 917392-54-2

Ref. TR-M325060

Product Information

• Name: Methyl 4-Methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate
• Synonyms: Benzoic acid, 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-, methyl ester, Nilotinib methyl ester,Benzoic acid, 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-, methyl ester, Methyl 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic Acid Ester, Nilotinib methyl ester
• Brand: TRC
• Description: Applications Methyl 4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzoate is an intermediate used in the synthesis of 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide (M326838), which is an impurity of Nilotinib (N465300), a possible agent in the treatment of chronic myelogenous leukemia.References Corbin, A., et al.: J. Biol. Chem., 277, 32214 (2002); Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005); Gleixner, K., et al.: Blood, 107, 752 (2006); Nicolini, F., et al.: Leukemia, 20, 1061 (2006)

Chemical properties

• Molecular weight: 320.35
• Formula: C₁₈H₁₆N₄O₂
• Color/Form: Neat
• InChI: InChI=1S/C18H16N4O2/c1-12-5-6-13(17(23)24-2)10-16(12)22-18-20-9-7-15(21-18)14-4-3-8-19-11-14/h3-11H,1-2H3,(H,20,21,22)
• InChI key: InChIKey=BECBKQYLJDEVDN-UHFFFAOYSA-N
• SMILES: COC(=O)c1ccc(C)c(Nc2nccc(-c3cccnc3)n2)c1