6-Methylthioguanine-d3

CAS: 1346601-96-4

Ref. TR-M330722

Product Information

• Name: 6-Methylthioguanine-d3
• Synonyms: 6-(Trideuteriomethylsulfanyl)-7H-purin-2-amine, 6-Methylthioguanine-D3 (methyl-D3), 2-Amino-6-(methyl-d3)thiopurine, 6-Trideuteromethylthioguanine

Description

Applications A labelled metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine. An effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.
References Loo, T.L. et al.: Cancer Chemother. Pharmacol., 6, 131 (1981); Yuan, B. et al.: ACS Chem. Biol., 5, 1021 (2010); Kroplin, T. et al.: Adv. Exp. Med. Biol., 431, 741 (1998);

• Brand: TRC

Chemical properties

• Molecular weight: 184.24
• Formula: C₆H₃H₄N₅S
• Color/Form: Neat
• InChI: InChI=1S/C6H7N5S/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)/i1D3
• InChI key: InChIKey=YEGKYFQLKYGHAR-FIBGUPNXSA-N
• SMILES: [2H]C([2H])([2H])Sc1nc(N)nc2nc[nH]c12