Methyl 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylate
CAS:
Ref. TR-M332848
25mg
176.00€
250mg
1,288.00€
Product Information
Name:Methyl 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylate
Controlled Product
Synonyms:
- Prucalopride Impurity D
Brand:TRC
Description:
Applications Methyl 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylate is an impurity of Prucalopride (P838950), a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe. In addition, it is an intermediate in the preparation of enterokinetic agent R108512.
References Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008), McKinnell, R., et al.: J. Med. Chem., 52, 5330 (2009), Shah, N., et al.: Am. J. Gastroenterol., 103, 1746 (2008); Willemsens, B. et al.: ACS Symp. Ser., 870, 125 (2004);
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Chemical properties
Molecular weight:277.64
Formula:C10H10ClNO3
Color/Form:Neat
InChI:InChI=1S/C10H10ClNO3/c1-14-10(13)6-4-7(11)8(12)5-2-3-15-9(5)6/h4H,2-3,12H2,1H3
InChI key:InChIKey=QCUNDLUTTXSPFM-UHFFFAOYSA-N
SMILES:O=Cc1cc2ccccc2cc1O
Technical inquiry about: Methyl 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylate
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