(9E)-9-[O-[(4-Methylphenyl)sulfonyl]oxime] Erythromycin

CAS: 227948-37-0

Ref. TR-M339125

Product Information

• Name: (9E)-9-[O-[(4-Methylphenyl)sulfonyl]oxime] Erythromycin
• Synonyms: [(E)-[(2R,3S,4R,5S,7R,9R,10R,11S,12S,13R)-10-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,9-trihydroxy-12-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-14-oxo-oxacyclotetradec-6-ylidene]amino] 4-methylbenzenesulfonate

Description

Applications (9E)-9-[O-[(4-Methylphenyl)sulfonyl]oxime] Erythromycin is an intermediate in the synthesis of Erythromycin A 9,11-Imino Ether (E650025). Erythromycin A 9,11-Imino Ether is an impurity in the synthesis of Erythromycin (E649950), a macrolide antibiotic with broad spectrum of antibacterial activity.
References Zhang, L. et al.: J. Antibio., 64, 243 (2011); Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979)

• Brand: TRC

Chemical properties

• Molecular weight: 903.128
• Formula: C₄₄H₇₄N₂O₁₅S
• Color/Form: Neat
• InChI: InChI=1S/C44H74N2O15S/c1-15-32-44(11,52)37(48)26(5)34(45-61-62(53,54)30-18-16-23(2)17-19-30)24(3)21-42(9,51)39(60-41-35(47)31(46(12)13)20-25(4)56-41)27(6)36(28(7)40(50)58-32)59-33-22-43(10,55-14)38(49)29(8)57-33/h16-19,24-29,31-33,35-39,41,47-49,51-52H,15,20-22H2,1-14H3/b45-34+/t24-,25-,26+,27+,28-,29+,31+,32-,33+,35-,36+,37-,38+,39-,41+,42-,43-,44-/m1/s1
• InChI key: InChIKey=WAZVMUGFTJEWAB-QJIYQREHSA-N
• SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N\OS(=O)(=O)c2ccc(C)cc2)[C@H](C)[C@@H](O)[C@]1(C)O