Product Information
Name:MK-8745
Controlled Product
Synonyms:
- (3-Chloro-2-fluorophenyl)[4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-piperazinyl]-methanone
- 1-(3-Chloro-2-fluorobenzoyl)-4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-piperazine
- 6-[[4-(3-Chloro-2-fluorobenzoyl)piperazin-1-yl]methyl]-N-(thiazol-2-yl)pyridin-2-amine
Brand:TRC
Description:Applications MK-8745 is a potent and selective Aurora A kinase inhibitor that induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.References Nair, J.S., et al.: Cell Cycle, 11, 807 (2012); Chowdhury, A., et al.: Leukemia Lymphoma, 53, 462 (2012)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:431.91
Formula:C20H19ClFN5OS
Color/Form:Neat
InChI:InChI=1S/C20H19ClFN5OS/c21-16-5-2-4-15(18(16)22)19(28)27-10-8-26(9-11-27)13-14-3-1-6-17(24-14)25-20-23-7-12-29-20/h1-7,12H,8-11,13H2,(H,23,24,25)
InChI key:InChIKey=YCRFPWKUUNKNDN-UHFFFAOYSA-N
SMILES:O=C(c1cccc(Cl)c1F)N1CCN(Cc2cccc(Nc3nccs3)n2)CC1
Technical inquiry about: MK-8745
Please use instead the cart to request a quotation or an order
If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.