Mono-tert-butyl Malonate

CAS: 40052-13-9

Ref. TR-M525030

Product Information

• Name: Mono-tert-butyl Malonate
• Synonyms: Propanedioic Acid 1-(1,1-Dimethylethyl) Ester, Propanedioic Acid Mono(1,1-dimethylethyl) Ester, 2-(tert-Butoxycarbonyl)acetic Acid, 3-tert-Butoxy-3-oxopropanoic Acid, Malonic Acid Mono-tert-butyl Ester, Malonic Acid tert-Butyl Monoester, tert-Butyl Hydrogen Malonate
• Brand: TRC
• Description: Applications Mono-tert-butyl Malonate is a useful synthetic intermediate. It can be used to prepare quinoline-based zinc metallo-aminopeptidase inhibitors with antimalarial activity. It can also be used to synthesize truncated aminoglycoside-CoA bisubstrate analogs via chemo- and regioselective coupling reaction of amine and thiols, as inhibitors of aminoglycoside 6'-N-acetyltransferase Ii Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Flipo, M., et al.: Bioorg. Med. Chem. Lett., 13, 2659 (2003); Gao, F., et al.: J. Med. Chem., 49, 5273 (2006)

Chemical properties

• Molecular weight: 160.17
• Formula: C₇H₁₂O₄
• Color/Form: Neat
• InChI: InChI=1S/C7H12O4/c1-7(2,3)11-6(10)4-5(8)9/h4H2,1-3H3,(H,8,9)
• InChI key: InChIKey=NGGGZUAEOKRHMA-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CC(=O)O