MPEP Hydrochloride

CAS: 219911-35-0

Ref. TR-M745805

Product Information

• Name: MPEP Hydrochloride
• Synonyms: 2-Methyl-6-(phenylethynyl)pyridine Hydrochloride, 2-Methyl-6-(phenylethynyl)pyridine hydrochloride, MPEP hydrochloride, Pyridine, 2-Methyl-6-(2-Phenylethynyl)-, Pyridine, 2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1), Pyridine, 2-methyl-6-(phenylethynyl)-, hydrochloride, Pyridine, 6-methyl-2-(phenylethynyl)-, 2-Methyl-6-(phenylethynyl)pyridine

Description

Stability Light Sensitive
Applications MPEP is a potent and highly selective non-competitive mGlu5a receptor antagonist (1,2). It is also a positive allosteric modulator at mGlu4 receptors.MPEP exhibits anxiolytic and antidepressant properties that may be applicable for treating schizophrenia (3).
References (1) Latif-Hemandez, A., et al.: Front Cell Neurosci. 10, 252 (2016)(2) Hikichi, H. et al.: Eur. J. Pharmacol., 639, 99 (2010)(3) Inta, I., et al.: Pharmacopsychiatry. 49, 142 (2016)

• Brand: TRC

Chemical properties

• Molecular weight: 229.7
• Formula: C₁₄H₁₂ClN
• Color/Form: Neat
• InChI: InChI=1S/C26H24F7N3O/c27-23-15-21(24(37,25(28,29)30)26(31,32)33)5-6-22(23)20-3-1-18(2-4-20)16-35-11-13-36(14-12-35)17-19-7-9-34-10-8-19/h1-10,15,37H,11-14,16-17H2
• InChI key: InChIKey=KVHKWAZUPPBMLL-UHFFFAOYSA-N
• SMILES: OC(c1ccc(-c2ccc(CN3CCN(Cc4ccncc4)CC3)cc2)c(F)c1)(C(F)(F)F)C(F)(F)F