Mycophenolic Acid-d3 β-D-Glucuronide

CAS: 31528-44-6

Ref. TR-M831522

Product Information

• Name: Mycophenolic Acid-d3 β-D-Glucuronide
• Synonyms: 5-[(2E)-5-Carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-(methoxy-d3)-7-methyl-3-oxo-4-isobenzofuranyl ß-D-Glucopyranosiduronic Acid, Mycophenolic Acid-d3 Glucosiduronate, Mycophenolic Acid-d3 Glucuronide

Description

Stability Hygroscopic
Applications A labelled metabolite of Mycophenolic Acid, an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.
References Senda, M., et al.: Transplantation, 60, 1143 (1995), Nimmesgern, E., et al.: J. Biol. Chem., 271, 19421 (1996), Gummert, J.F., et al.: J. Pharmacol. Exp. Ther., 291, 1100 (1999),

• Brand: TRC

Chemical properties

• Molecular weight: 499.48
• Formula: C₂₃H₂₅D₃O₁₂
• Color/Form: White To Light Grey
• InChI: InChI=1S/C23H28O12/c1-9(5-7-13(24)25)4-6-11-18(32-3)10(2)12-8-33-22(31)14(12)19(11)34-23-17(28)15(26)16(27)20(35-23)21(29)30/h4,15-17,20,23,26-28H,5-8H2,1-3H3,(H,24,25)(H,29,30)/b9-4+/t15-,16-,17+,20-,23+/m0/s1/i3D3
• InChI key: InChIKey=BYFGTSAYQQIUCN-FPXLKDJASA-N
• SMILES: [2H]C([2H])([2H])Oc1c(C)c2c(c(O[C@@H]3O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]3O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2