Nalfurafine N-Oxide

CAS: 208042-42-6

Ref. TR-N255605

Product Information

• Name: Nalfurafine N-Oxide
• Synonyms: (2E)-N-[(5α,6β)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-oxidomorphinan-6-yl]-3-(3-furanyl)-N-methyl-2-propenamide
• Brand: TRC
• Description: Stability HygroscopicApplications Nalfurafine N-Oxide, is an impurity of Nalfurafine (N255600), which is a κ-opioid receptor agonist marketed as a treatment for uremic pruritus in hemodialysis patients.References Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004), Mori, T., et al.: Life Sci., 75, 2433 (2004), Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2006), Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2010),

Chemical properties

• Molecular weight: 492.56
• Formula: C₂₈H₃₂N₂O₆
• Color/Form: Neat
• InChI: InChI=1S/C28H32N2O6/c1-29(23(32)7-4-18-9-13-35-16-18)20-8-10-28(33)22-14-19-5-6-21(31)25-24(19)27(28,26(20)36-25)11-12-30(22,34)15-17-2-3-17/h4-7,9,13,16-17,20,22,26,31,33H,2-3,8,10-12,14-15H2,1H3/b7-4+/t20-,22-,26+,27+,28-,30?/m1/s1
• InChI key: InChIKey=MWDGJQVNEHFHMK-MBBMFRJGSA-N
• SMILES: CN(C(=O)/C=C/c1ccoc1)[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CC[N+]3([O-])CC2CC2)[C@H]1O5