Product Information
- (4S)-4-[(1R)1-Hydroxy-2-[[1-[3-(1-methylethyl)phenyl]cyclopropyl]amino]ethyl]-19-methyl-11,16-dioxa-3,18-diazatricyclo[15.3.1.16,10]docosa-1(21),6,8,10(22),17,19-hexaen-2-one
- (4S)-4-[(1R)-1-Hydroxy-2-[[1-(3-isopropylphenyl)cyclopropyl]amino]ethyl]-19-methyl-11,16-dioxa-3,18-diazatricyclo[15.3.1.16,10]docosa-1(21),6,8,10(22),17,19-hexaen-2-one
Applications NB-851 is a macrocyclic BACE-1 inhibitor reducing Aβ in brain after administration. Potential treatment for the prevention or maintenance of Alzheimer’s disease.
References Lerchner, A. et al.: Bioorg. Med. Chem. Lett., 20, 603 (2010);
Chemical properties
Technical inquiry about: TR-N381200 NB-851
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