Necrostatin-1

CAS: 4311-88-0

Ref. TR-N388550

Product Information

• Name: Necrostatin-1
• Synonyms: 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one, MTH-DL-Tryptophan Methylthiohydantoin-DL-tryptophan, 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxoimidazolidin-4-one, 5-(1H-Indol-3-Ylmethyl)-3-Methyl-2-Thioxo-4-Imidazolidinone

Description

Applications Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.
References Foresti, R., et al: J. Biol. Chem., 272, 18411 (1997); Cardenas, A., et al.: J. Neurochem., 74, 2041 (2000); Degterev, et al.: Nat. Chem. Biol., 1, 112 (2005); Hitomi, J., et al.: Cell, 135, 1311 (2008);

• Brand: TRC

Chemical properties

• Molecular weight: 259.33
• Formula: C₁₃H₁₃N₃OS
• Color/Form: Neat
• InChI: InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
• InChI key: InChIKey=DHIVJYNSSSHXRG-UHFFFAOYSA-N
• SMILES: CC(=O)c1ccc2c(c1)C(C)(C)CCS2