Product Information
Name:Necrostatin-1
Controlled Product
Synonyms:
- 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
Brand:TRC
Description:Applications Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.References Foresti, R., et al: J. Biol. Chem., 272, 18411 (1997); Cardenas, A., et al.: J. Neurochem., 74, 2041 (2000); Degterev, et al.: Nat. Chem. Biol., 1, 112 (2005); Hitomi, J., et al.: Cell, 135, 1311 (2008);
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Chemical properties
Molecular weight:259.33
Formula:C13H13N3OS
Color/Form:Neat
InChI:InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChI key:InChIKey=DHIVJYNSSSHXRG-UHFFFAOYSA-N
SMILES:CC(=O)c1ccc2c(c1)C(C)(C)CCS2
Technical inquiry about: Necrostatin-1
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