Product Information
Name:β-Nicotinamide Mononucleotide-13C5
Controlled Product
Synonyms:
- [(2R,3R,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy(2,3,4,5-13C4)oxolan-2-yl](113C)methyl hydrogen phosphate
Brand:TRC
Description:Applications The labelled analogue of a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.References Yoshino, J. et al.: Cell Metab., 14, 528 (2011); Caton, P.W. et al.: Diabetologia, 54, 3083 (2011); Formentini, L. et al.: BIochem. Pharmacol., 77, 1612 (2009);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:339.182
Formula:C5C6H15N2O8P
Color/Form:Neat
InChI:InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8+,9-,11-/m1/s1/i5+1,7+1,8+1,9+1,11+1
SMILES:NC(=O)c1ccc[n+]([13C@@H]2O[13C@H]([13CH2]OP(=O)([O-])O)[13C@H](O)[13C@H]2O)c1
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