Product Information
Name:NS-2028
Controlled Product
Synonyms:
- 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
Brand:TRC
Description:Applications NS-2028 potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). NS-2028 blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA. NS-2028 inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).References Olesen, et al.: Br. J. Pharmacol., 123, 299 (1998), von Wantoch Rekowski, et al.: Bioorg. Med. Chem. 18, 1288 (2010),
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Chemical properties
Molecular weight:269.05
Formula:C9H5BrN2O3
Color/Form:Neat
InChI:InChI=1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2
InChI key:InChIKey=MUDRLQRJCGJJTB-UHFFFAOYSA-N
SMILES:O=c1onc2n1-c1cc(Br)ccc1OC2
Technical inquiry about: NS-2028
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