Product Information
Name:NU6027
Controlled Product
Synonyms:
- 6-(Cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine
- 2,6-Diamino-4-(cyclohexylmethoxy)-5-nitrosopyrimidine
- 6-(Cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine
Brand:TRC
Description:Applications NU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitorsReferences Arris, C.E., et. al.: J. Med. Che., 43, 2797 (2000); Peasland, A., et. al.: Brit. J. Cancer, 105, 372 (2011)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:251.285
Formula:C11H17N5O2
Color/Form:Neat
InChI:InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15)
InChI key:InChIKey=DGWXOLHKVGDQLN-UHFFFAOYSA-N
SMILES:Nc1nc(N)c(N=O)c(OCC2CCCCC2)n1
Technical inquiry about: NU6027
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