Product Information
Name:
NVP-AUY 922
Synonyms:
- VER 52296
- NVP-AUY922
- 3-Isoxazolecarboxamide, 5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-
- 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide
- 5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide
- Auy 922
- Luminespib
- Nvp-Auy 922
- Nvp-Auy 922Nx
- Nvp-Auy922
- See more synonyms
- Nvr-Auy 922
- Ver 52296
Description:
Applications NVP-AUY 922 is a potent inhibitor of heat shock protein 90 (Hsp90) that prevents the proliferation of a range of human cancer cell lines. NVP-AUY 922 has been shown to enhance the radiation sensitivity of tumor cell lines under hypoxia. Potent Hedgehog inhibitor.
References Djuzenova, C.S. et al.: Cencer Biol. Ther., 13, 425 (2012); Lee, K.-K. et al.: Cancer Sci., 102, 1388 (2011); Okui, T. et al.: Anticancer Res., 31, 1197 (2011);
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
465.54
Formula:
C26H31N3O5
Color/Form:
Off-WHite to Pale Beige Solid
InChI:
InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)
InChI key:
InChIKey=NDAZATDQFDPQBD-UHFFFAOYSA-N
SMILES:
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(CN2CCOCC2)cc1
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