5-Nitro-2-(propylthio)pyrimidin-4-ol

Ref. TR-N926630

Product Information

• Name: 5-Nitro-2-(propylthio)pyrimidin-4-ol
• Synonyms: 5-nitro-2-propylsulfanylpyrimidin-4-ol

Description

Applications 5-Nitro-2-(propylthio)pyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).
References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)

• Brand: TRC

Chemical properties

• Molecular weight: 215.23
• Formula: C₇H₉N₃O₃S
• Color/Form: Neat
• InChI: InChI=1S/C7H9N3O3S/c1-2-3-14-7-8-4-5(10(12)13)6(11)9-7/h4H,2-3H2,1H3,(H,8,9,11)
• SMILES: CCCSc1ncc([N+](=O)[O-])c(O)n1