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Octyl-α-hydroxyglutarate

Ref. TR-O287590

100mg
3,477.00€
Octyl-α-hydroxyglutarate
TRC

    Product Information

    Name:Octyl-α-hydroxyglutarate
    Controlled Product
    Synonyms:
    • Octyl-2-HG
    Brand:TRC
    Description:Applications Octyl-α-hydroxyglutarate is a cell-permeable derivative of 2-HG (α-hydroxyglutaric acid). Mutations in isocitrate dehydrogenase 1 (IDH1 and IDH2) associated with certain cancers cause isocitrate to metabolize into 2-HG as opposed α-ketoglutarate, inhibiting α-ketoglutarate-dependant dioxygenases including lysine demethylases and DNA hydroxylases. This compound is suitable for IDH (isocitrate dehydrogenase) related research.References Struys, E. et al.: Clin. Chem., 49, 1133 (2003); Ward, P. et al.: Cancer Cell., 17, 225 (2010);
    Notice:Our products are intended for lab use only. For any other use, please contact us.

    Chemical properties

    Molecular weight:260.327
    Formula:C13H24O5
    Color/Form:Neat
    InChI:InChI=1S/C13H24O5/c1-2-3-4-5-6-7-10-18-13(17)11(14)8-9-12(15)16/h11,14H,2-10H2,1H3,(H,15,16)
    InChI key:InChIKey=UJZOKTKSGUOCCM-UHFFFAOYSA-N
    SMILES:CCCCCCCCOC(=O)C(O)CCC(=O)O

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