Olopatadine Isopropyl Ester-d6

CAS: 1206456-44-1

Ref. TR-O575027

Product Information

• Name: Olopatadine Isopropyl Ester-d6
• Synonyms: propan-2-yl 2-[(11Z)-11-[3-[bis(trideuteriomethyl)amino]propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetate

Description

Applications Olopatadine Isopropyl Ester-d6 is labelled Olopatadine Isopropyl Ester (O575025), an intermediate used to prepare Olopatadine (O575000, HCl salt) via Wittig reaction. Olopatadine is a dual acting histamine H1-receptor antagonist and mast cell stabilizer.
References Kamei, C., et al.: Arzneim.-Forsch., 45, 1005 (1995); Sharif, N.A., et al.: J. Pharmacol. Exp. Ther., 278, 1252 (1996); Abelson, M.B., et al.: Am. J. Ophthalmol., 125, 797 (1998); Silva, G., et al.: Eur. Pat. Appl., EP 2145882 A1 20100120 (2010)

• Brand: TRC

Chemical properties

• Molecular weight: 385.529
• Formula: C₂₄D₆H₂₃NO₃
• Color/Form: Neat
• InChI: InChI=1S/C24H29NO3/c1-17(2)28-24(26)15-18-11-12-23-22(14-18)21(10-7-13-25(3)4)20-9-6-5-8-19(20)16-27-23/h5-6,8-12,14,17H,7,13,15-16H2,1-4H3/b21-10-/i3D3,4D3
• InChI key: InChIKey=AEZOYXJGZPHCRI-IPYDIYGUSA-N
• SMILES: [2H]C([2H])([2H])N(CC/C=C1/c2ccccc2COc2ccc(CC(=O)OC(C)C)cc21)C([2H])([2H])[2H]