Oridonin

CAS: 28957-04-2

Ref. TR-O674700

Product Information

• Name: Oridonin
• Synonyms: Kaur-16-en-15-one, 7,20-epoxy-1,6,7,14-tetrahydroxy-, (1α,6β,7α,14R)-, Kaur-16-en-15-one, 7α,20-epoxy-1α,6β,7,14-tetrahydroxy-, (14R)- (8CI), Oridonin (7CI), 6,11b-(Epoxymethano)-6a,9-methano-1H-cyclohepta[a]naphthalene, kaur-16-en-15-one deriv., (1α,6β,7α,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one, Isodonol, NSC 250682, Oridonine, (1alpha,5beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one, (1alpha,5beta,6beta,7beta,9xi,10xi,14S)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one, (1alpha,5beta,6beta,9beta,14S)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one, (6Beta,7Beta)-1,6,7,14-Tetrahydroxy-7,20-Epoxykaur-16-En-15-One, 6,11b-(Epoxymethano)-6a,9-methano-1H-cyclohepta[a]naphthalene, kaur-16-en-15-one deriv., Isodonal, Kaur-16-en-15-one, 7,20-epoxy-1,6,7,14-tetrahydroxy-, (1α,6β,7α,14R)-, Kaur-16-en-15-one, 7α,20-epoxy-1α,6β,7,14-tetrahydroxy-, (14R)-, rubescensin A
• CAS: 28957-04-2

Description

Applications Oridonin is an effective anticancer agent due to its ability to inhibit proliferation and induce apoptosis of human osteosarcoma cells. Blocks Wnt/β-catenin signalling.
References Liu, Y. et al.: Int. J. Onc., 45, 795 (2014);

• Brand: TRC

Chemical properties

• Molecular weight: 364.43
• Formula: C₂₀H₂₈O₈
• Color/Form: White to Off-White Solid
• InChI: InChI=1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1
• InChI key: InChIKey=SDHTXBWLVGWJFT-CAYOSMHYSA-N
• SMILES: C=C1C(=O)[C@@]23C(CC[C@@H]1[C@H]2O)[C@@]12CO[C@]3(O)[C@@H](O)[C@@H]1C(C)(C)CC[C@@H]2O