CAS 28957-04-2
:Oridonin
Description:
Oridonin is a natural compound classified as a diterpenoid, primarily derived from the plant Rabdosia rubescens, which is known for its traditional medicinal uses in Chinese herbal medicine. This compound exhibits a range of biological activities, including anti-inflammatory, anti-tumor, and antimicrobial properties, making it a subject of interest in pharmacological research. Oridonin's structure features a fused ring system typical of many diterpenoids, contributing to its biological activity. It is soluble in organic solvents but has limited solubility in water, which can influence its bioavailability and therapeutic applications. The compound has been studied for its potential effects on various cancer cell lines, showing promise in inducing apoptosis and inhibiting cell proliferation. Additionally, oridonin's mechanism of action may involve the modulation of signaling pathways related to cell survival and death. Overall, oridonin represents a significant area of interest for further research in drug development and natural product chemistry.
Formula:C20H28O6
InChI:InChI=1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13?,15+,16?,18+,19-,20+/m0/s1
InChI key:InChIKey=SDHTXBWLVGWJFT-VSKLWXMZSA-N
SMILES:O[C@]12[C@]34[C@]([C@]5(C([C@@H]1O)(C(C)(C)CC[C@@H]5O)[H])CO2)(CC[C@]([C@H]3O)(C(=C)C4=O)[H])[H]
Synonyms:- (1alpha,5beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one
- (1alpha,5beta,6beta,7beta,9xi,10xi,14S)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one
- (1alpha,5beta,6beta,9beta,14S)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one
- (1α,6β,7α,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one
- (6Beta,7Beta)-1,6,7,14-Tetrahydroxy-7,20-Epoxykaur-16-En-15-One
- 6,11b-(Epoxymethano)-6a,9-methano-1H-cyclohepta[a]naphthalene, kaur-16-en-15-one deriv.
- Isodonal
- Isodonol
- Kaur-16-en-15-one, 7,20-epoxy-1,6,7,14-tetrahydroxy-, (1α,6β,7α,14R)-
- Kaur-16-en-15-one, 7α,20-epoxy-1α,6β,7,14-tetrahydroxy-, (14R)-
- NSC 250682
- Oridonine
- rubescensin A
- See more synonyms
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Oridonine
CAS:Formula:C20H28O6Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:364.44Oridonin
CAS:Oridonin has anticancer activity, might be useful as adjunctive therapy for individuals with lymphoid malignancies, including the lethal disease adult T-cell leukemia.It inhibits tumor growth in glioma by inducing cell cycle arrest and apoptosis, inhibits BxPC-3 cell growth through cell apoptosis.Formula:C20H28O6Purity:95%~99%Molecular weight:364.438Oridonin (Standard)
CAS:Oridonin (Standard) is a reference standard for research and analysis in studies involving Oridonin. Oridonin (NSC-250682) is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.Formula:C20H28O6Color and Shape:SolidMolecular weight:364.4327(1α,6β,7α,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one
CAS:Formula:C20H28O6Purity:98%Color and Shape:SolidMolecular weight:364.4327Oridonin
CAS:Oridonin, a diterpenoid from Rabdosia rubescens, has anti-tumor, anti-bacterial, and anti-inflammatory properties, inhibiting AKT1/2.Formula:C20H28O6Purity:94.25% - >99.99%Color and Shape:SolidMolecular weight:364.4327Oridonin
CAS:(1α,6β,7α,14R)-1,5,6,14-Tetrahydroxy-4,4-dimethyl-8-methylenedecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-7(8H)-oneFormula:C20H28O6Purity:99%Molecular weight:364.43Oridonin
CAS:Oxygen-heterocyclic compoundFormula:C20H28O6Purity:≥ 98.0 % (HPLC)Color and Shape:PowderMolecular weight:364.44Oridonin - Bio-X ™
CAS:This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C20H28O6Purity:Min. 95%Color and Shape:PowderMolecular weight:364.44 g/molOridonin
CAS:A diterpenoid from Chinese medicinal plant Rabdosia rubescens with anti-inflammatory activity. It is a potent inhibitor of NF-κB and MAPK activation and suppresses the release of proinflammatory cytokines. It is also a covalent inhibitor of NLRP3, a sensor component of NLRP3 inflammasome. In a rodent model for cerebral amyloidosis, oridonin effectively prevented neuroinflammation and Alzheimer’s disease-associated neuropathological changes. It reduced numbers of amyloid-β plaques in mice brain and reversed behaviour and social impairment.
Formula:C20H28O6Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:364.44 g/molOridonin
CAS:Controlled ProductApplications Oridonin is an effective anticancer agent due to its ability to inhibit proliferation and induce apoptosis of human osteosarcoma cells. Blocks Wnt/β-catenin signalling.
References Liu, Y. et al.: Int. J. Onc., 45, 795 (2014);Formula:C20H28O6Color and Shape:NeatMolecular weight:364.43
