Oxaliplatin

CAS: 61825-94-3

Ref. TR-O845075

Product Information

• Name: Oxaliplatin
• Synonyms: (SP-4-2)-[(1R,2R)-Cyclohexane-1,2-diamine-kappaN,kappaN'][ethanedioato(2-)-kappaO1,kappaO2]platinum, Oxalato(trans-(-)-1,2-cyclohexanediamine)platinum(II), Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]-, (SP-4-2)-, platinum(2+) ethanedioate (1R,2R)-cyclohexane-1,2-diamine (1:1), NSC-266046, [SP-4-2-(IR-trans)]-(1,2-cyclohexanediamine-n,n')[ethanedioato(2-)-O,O']-platinum, (1R,2R)-cyclohexane-1,2-diamine: oxalic acid: platinum(+2) cation, xalatoplatinum, (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]platinum, Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN,κN′][ethanedioato(2-)-κO1,κO2]-, (SP-4-2)-, latin, cyclohexane-1,2-diamine: oxalic acid: platinum, RP-54780, (sp-4-2)-((1r,2r)-1,2-cyclohexanediamine-n,n')(ethanedioato(2-)-O,O']platinum, Platinum, (1,2-cyclohexanediamine-N,N′)[ethanedioato(2-)-O,O′]-, [SP-4-2-(1R-trans)]-, platinum(4+) cyclohexane-1,2-diyldiazanide ethanedioate (1:1:1), Elocatin, Oxalipatin, trans-L-Diaminocyclohexane oxalatoplatinum, 1,2-Cyclohexanediamine, platinum complex, (1R-trans)-, ι-OHP

Description

Applications Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),

• Brand: TRC

Chemical properties

• Molecular weight: 397.29
• Formula: C₈H₁₄N₂O₄Pt
• Color/Form: White To Off-White
• InChI: , +2/p-2/t5-,6-, /h5-6H,1-4,7-8H2, InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8, (H,3,4)(H,5,6), /q, /m1../s1, , 3-1(4)2(5)6
• InChI key: InChIKey=ZROHGHOFXNOHSO-BNTLRKBRSA-L