(S,S)-Oxaliplatin

CAS: 61758-77-8

Ref. TR-O845080

Product Information

• Name: (S,S)-Oxaliplatin
• Synonyms: Platinum, [(1S,2S)-1,2-cyclohexanediamine-kappaN1,kappaN2][ethanedioato(2-)-kappaO1,kappaO2]-, (SP-4-2)-, Platinum, (1,2-cyclohexanediamine-kappaN,kappaN')[ethanedioato(2-)-kappaO1,kappaO2]-, [SP-4-2-[1S-(trans)]]-, Platinum, [(1S,2S)-1,2-cyclohexanediamine-kappaN,kappaN'][ethanedioato(2-)-kappaO1,kappaO2]- (9CI), 1,2-Cyclohexanediamine, platinum complex, (1S-trans)-, [(1S,2S)-1,2-Cyclohexanediamine-kappaN1,kappaN2][ethanedioato(2-)-kappaO1,kappaO2]platinum, NSC 266042, Platinum, (1,2-cyclohexanediamine-N,N')[ethanedioato(2-)-O,O']-, [SP-4-2-(1S-trans)]-, (SP-4-2)-[(1S,2S)-Cyclohexane-1,2-diamine-kappaN,kappaN'][ethanedioato(2-)-kappaO1,kappaO2]platinum, Oxaliplatin Imp. D (EP), Oxaliplatin Related Compound D (USP)

Description

Applications The (S,S) Oxaliplatin isomer. Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),

• Brand: TRC

Chemical properties

• Molecular weight: 397.29
• Formula: C₈H₁₄N₂O₄Pt
• Color/Form: White
• InChI: /q, /h5-6H,1-4,7-8H2, , InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8, , +2/p-2/t5-,6-, (H,3,4)(H,5,6), /m0../s1, 3-1(4)2(5)6
• InChI key: InChIKey=ZROHGHOFXNOHSO-USPAICOZSA-L