TR-O991288 - 1-oxa-8-azaspiro55undecane | 70399-19-8

<p>OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).</p>

<p>Orexin-A (also known as hypocretin-1) is a hypothalamic neuropeptide that regulates feeding behaviour, reward processes, cognition, the sleep-wake cycle and stress. Orexin-A is involved in stress induced mental illness such as major depressive disorder and anxiety disorders and may therefore be a potential target for treatment of these conditions.Orexins are excitatory neuropeptides generated from the prepro-orexin precursor that is exclusively localised in cells of the lateral and posterior hypothalamic region. Orexins are also widely expressed in human and mammalian retinas, such as bipolar cells, amacrine cells and ganglion cells.Orexin-A activates the orphan G-protein-coupled orexin receptor, type 1 (OX1R) and 2 (OX2R). There are approximately 10,000-20,000 orexinergic neurons in the human brain.</p>

<p>Oxa 06 dihydrochloride is an anticancer agent that acts as a kinase inhibitor. It is a synthetic analog of menthol and has been shown to be effective against various types of cancer cells, inducing apoptosis and inhibiting tumor growth. Oxa 06 dihydrochloride specifically targets human cancer cells and has been found to be present in urine after administration. This potent inhibitor of protein kinases has potential therapeutic applications in the treatment of cancer. Studies have shown that Oxa 06 dihydrochloride can inhibit the growth of Chinese hamster ovary cells and human lung carcinoma cells. Additionally, it has been found to be effective when used in combination with other inhibitors, suggesting its potential for use in combination therapies for cancer treatment.</p>

<p>This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci</p>

<p>1-Oxa-6-azaspiro[3.4]octane oxalate is used as a pharmaceutical intermediate in synthetic chemistry. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aes</p>

<p>2-Oxa-6-azaspiro[3.4]octane is involved in the preparation of azaspirocycle or azetidine substituted 4-anilinoquinazoline derivatives, which exhibits epidermal growth factor receptor (EGFR) inhibitory activities. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar pr</p>

<p>This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci</p>

<p>Spiro forms of oxazines find applications as leuco dyes, by frequently displaying chromism - reversibly interchanging between their colorless and colored forms. Spiro compounds are used as photo chromic materials. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar </p>

<p>Spiro forms of lactones and oxazines find applications as leuco dyes, by frequently displaying chromism - reversibly interchanging between their colorless and colored forms. Spiro compounds are used as photochromic materials. This Thermo Scientific Chemicals brand product was originally part of the </p>

<p>2-Oxa-6-azaspiro[3.3]heptane oxalate used as a intermediate in pharmaceutical and chemical synthesis. Also used in medicine. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand.</p>

<p>8-Oxa-3-azabicyclo[3.2.1]octane hydrochloride is employed as a important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentatio</p>

<p>(4S,5S)-2-Chloro-3,4-dimethyl-2,5-diphenyl-1-oxa-3-aza-2-silacyclopentane, min. 98% (~2:1 mixture of diastereomers)</p>

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Aromatic or modified aromatic heterocyclic compounds with nitrogen hetero atom(s) only, except acridine, indole and carbazole