Paclitaxel-d5

CAS: 1129540-33-5

Ref. TR-P132502

Product Information

• Name: Paclitaxel-d5
• Synonyms: Paclitaxel-D5 (benzoylamino-D5),Benzenepropanoic acid, ß-(benzoyl-2,3,4,5,6-d5-amino)-a-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (aR,ßS)-, (2R,3S)-3-(Benzoyl-2,3,4,5,6-d5-amino)-2-hydroxy-3-phenylpropanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester

Description

Applications Labelled Paclitaxel (P132500). An antineoplastic. Used in the study of structure and function of microtubles into tubulin.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

• Brand: TRC

Chemical properties

• Molecular weight: 858.94
• Formula: C₄₇H₅H₄₆NO₁₄
• Color/Form: Neat
• InChI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1/i8D,12D,13D,18D,19D
• InChI key: InChIKey=RCINICONZNJXQF-YDHIBJABSA-N
• SMILES: [2H]c1c([2H])c([2H])c(C(=O)N[C@@H](c2ccccc2)[C@@H](O)C(=O)O[C@H]2C[C@@]3(O)[C@H](OC(=O)c4ccccc4)[C@@H]4C5(OC(C)=O)COC5C[C@H](O)[C@@]4(C)C(=O)[C@H](OC(C)=O)C(=C2C)C3(C)C)c([2H])c1[2H]