Pemetrexed Disodium Heptahydrate

CAS: 357166-29-1

Ref. TR-P219550

Product Information

• Name: Pemetrexed Disodium Heptahydrate
• Synonyms: L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, sodium salt, hydrate (1:2:7), L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate (9CI), Disodium (2S)-2-[[4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate heptahydrate, Pemetrexed disodium hepthydrate, Pemetrexed disodium heptahydrate
• CAS: 357166-29-1

Description

Applications Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.
References Vogelzang, N.J., et al.: J. Clin. Oncol., 21,2636 (2003); Paz-Ares, L., et al.: Lancet. Oncol., 13, 247 (2012);

• Brand: TRC

Chemical properties

• Molecular weight: 597.48
• Formula: C₂₀H₃₃N₅Na₂O₁₃
• Color/Form: White to Off-White Solid
• InChI: , /h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29), , , , , , , , , , , /m0........./s1, /p-2/t13-, , , , , 2*+1, InChI=1S/C20H21N5O6.2Na.7H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27, 7*1H2/q, , , , , , , , ,
• SMILES: Nc1nc(=O)c2c(CCc3ccc(C(=O)NC(CCC(=O)[O-])C(=O)[O-])cc3)c[nH]c2[nH]1.O.O.O.O.O.O.O.[Na+].[Na+]