N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester

CAS: 1334513-02-8

Ref. TR-P270355

Product Information

• Name: N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester
• Synonyms: (2S)-Isopropyl 2-(((Perfluorophenoxy)(Phenoxy)Phosphoryl)Amino)Propanoate
• Brand: TRC

Description

Applications N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is a reactant in the synthesis of phosphoramidate imidazo[2,1-f][1,2,4]triazine-4-amine adenosine prodrugs that can increase anti-HCV activity.
References Tyndall, E.M., et. al.: Bio. Med. Chem. Lett., 25, 869 (2015)

Chemical properties

• Molecular weight: 453.3
• Formula: C₁₈H₁₇F₅NO₅P
• Color/Form: Neat
• InChI: InChI=1S/C18H17F5NO5P/c1-9(2)27-18(25)10(3)24-30(26,28-11-7-5-4-6-8-11)29-17-15(22)13(20)12(19)14(21)16(17)23/h4-10H,1-3H3,(H,24,26)/t10-,30-/m0/s1
• InChI key: InChIKey=PCPLMRKVBFMLEU-YDALLXLXSA-N
• SMILES: CC(C)OC(=O)[C@H](C)NP(C)(C)(Oc1ccccc1)Oc1c(F)c(F)c(F)c(F)c1F.[O]