Product Information
Name:PF 670462
Controlled Product
Synonyms:
- 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine Dihydrochloride
Brand:TRC
Description:Applications PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.References Bryant, D.D. et al.: Psychopharmacology, 203, 703 (2009); Badura, L. et al.: J. Pharmacol. Exp. Therap., 322, 730 (2007); Sprouse, J. et al.: Psychopharmacology, 210, 569 (2010):
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:410.32
Formula:C19H22Cl2FN5
Color/Form:Neat
InChI:InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H
InChI key:InChIKey=PSNKGVAXBSAHCH-UHFFFAOYSA-N
SMILES:Cl.Cl.Nc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCCCC2)n1
Technical inquiry about: PF 670462
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