Estimated delivery in United States, on Tuesday 25 Jun 2024
Product Information
Name:
PF 670462
Synonyms:
- 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine Dihydrochloride
- 2-Pyrimidinamine, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-, hydrochloride (1:2)
- 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride
- Pf670462
- Pf 670462
CAS:
Description:
Applications PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.
References Bryant, D.D. et al.: Psychopharmacology, 203, 703 (2009); Badura, L. et al.: J. Pharmacol. Exp. Therap., 322, 730 (2007); Sprouse, J. et al.: Psychopharmacology, 210, 569 (2010):
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
410.32
Formula:
C19H22Cl2FN5
Color/Form:
Neat
InChI:
InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H
InChI key:
InChIKey=PSNKGVAXBSAHCH-UHFFFAOYSA-N
SMILES:
Cl.Cl.Nc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCCCC2)n1
MDL:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-P293960 PF 670462
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