Product Information
- 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
Applications PFK 15 is a novel inhibitor of glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3). It suppresses the glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and induces apoptosis in abnormal cells.
References Clem, B., et al.: Mol. Cancer Ther., 12, 1461 (2013); Brooke, D., et al.: Bioorg. Med. Chem., 22, 1029 (2014);
Chemical properties
Technical inquiry about: TR-P294095 PFK 15
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