PHA 767491 Dihydrochloride Salt

CAS: 3942425-68-5

Ref. TR-P294450

Product Information

• Name: PHA 767491 Dihydrochloride Salt
• Synonyms: PF-02334471

Description

Stability Hygroscopic
Applications A potent and selective ATP-competitive dual inhibitor cdc7/cdk9. It blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2).
References Anderson, D.R. et al.: J. Med. Chem., 50, 2647 (2007); Montagnoli, A. et al.: Nature Chem. Biol., 4, 357 (2008); Charych, D.H. et al.: J Cell. Biochem., 104, 1075 (2008); Jackson, P.K. et al.: Nature Chem. Biol., 4, 331 (2008);

• Brand: TRC

Chemical properties

• Molecular weight: 286.16
• Formula: C₁₂H₁₁N₃OClH
• Color/Form: Light Yellow Powder
• InChI: InChI=1S/C12H11N3O.2ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;;/h1-2,4-5,7,15H,3,6H2,(H,14,16);2*1H
• InChI key: InChIKey=KSKNLCXPGIARKA-UHFFFAOYSA-N
• SMILES: Cl.Cl.O=C1NCCc2[nH]c(-c3ccncc3)cc21