4-Phospho D-Erythronate

CAS: 57229-25-1

Ref. TR-P355000

Product Information

• Name: 4-Phospho D-Erythronate
• Synonyms: (2R,3R)-2,3-Dihydroxy-4-(phosphonooxy)butanoic Acid, [R-(R*,R*)]-2,3-Dihydroxy-4-(phosphonooxy)butanoic Acid

Description

Applications 4-Phospho-D-erythronate is an intermediate in the synthesis of pyridoxal 5'-phosphate in some bacteria and an inhibitor of ribose 5-phosphate isomerase. Phosphorylated aldonic acids are strong inhibitors of 6-phosphogluconate dehydrogenase, and 4-phospho-D-erythronate (4PE) and 4-phospho-D-erythronohydroxamate are two of the strongest inhibitors of the Trypanosoma brucei enzyme.
References Tanaka, N., et al.: J. Mol. Biol., 324, 519 (2002), Fitzpatrick, T., et al.: Biochem. J., 407, 1 (2007), Kalliri, E., et al.: J. Bacteriol., 190, 3793 (2008),

• Brand: TRC

Chemical properties

• Molecular weight: 216.08
• Formula: C₄H₉O₈P
• Color/Form: Colourless
• InChI: InChI=1S/C4H9O8P/c5-2(3(6)4(7)8)1-12-13(9,10)11/h2-3,5-6H,1H2,(H,7,8)(H2,9,10,11)/t2-,3-/m1/s1
• InChI key: InChIKey=ZCZXOHUILRHRQJ-PWNYCUMCSA-N
• SMILES: O=C(O)[C@H](O)[C@H](O)COP(=O)(O)O