Pimozide

CAS: 2062-78-4

Ref. TR-P447800

Product Information

• Name: Pimozide
• Synonyms: 2H-Benzimidazol-2-one, 1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-, 2-Benzimidazolinone, 1-[1-[4,4-bis(p-fluorophenyl)butyl]-4-piperidyl]- (7CI,8CI), 1-(1-(4,4-Bis(4-fluorophenyl)butyl)-4-piperindinyl)-1,3-dihydro-2H-benzimidazol-2-one, 1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone, 1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine, NSC 170984, Orap, Primozide, R 6238, 1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one, 1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazole-2-one, 2-Benzimidazolinone, 1-[1-[4,4-bis(p-fluorophenyl)butyl]-4-piperidyl]-, Apo-Pimozide, Nsc 170984, Pimozid, Pimozida, 2H-Benzimidazol-2-one, 1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-

Description

Applications Pimozide is a D2 dopamine receptor antagonist that binds to the cloned 5-HT7 receptor with high affinity (1,2,3,4). Pimozide is also a Ca2+ channel antagonist. Pimozide is used as an antipsychotic.
References (1) Nikonenko, I., et al.: Mol. Pharmacol., 68, 84 (2005) (2) Mariot, P., et al.: J. Biol. Chem., 277, 10824 (2002) (3) Liu, J., et al.: Br. J. Pharmacol., 126, 245 (1999) (4) Santi, C., et al.: J. Neurosci., 22, 396 (2002)

• Brand: TRC

Chemical properties

• Molecular weight: 461.55
• Formula: C₂₈H₂₉F₂N₃O
• Color/Form: Off-White
• InChI: InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
• InChI key: InChIKey=YVUQSNJEYSNKRX-UHFFFAOYSA-N
• SMILES: O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1