Pimozide-d5 (Major)

CAS: 1794979-08-0

Ref. TR-P447802

Product Information

• Name: Pimozide-d5 (Major)
• Synonyms: 1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one-d5, 1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone-d5, 1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine-d5, NSC 170984-d5, Orap-d5, Primozide-d5, R 6238-d5

Description

Applications Labelled analogue of Pimozide, a D2 dopamine receptor antagonist. Pimozide binds with high affinity to the cloned 5-HT7 receptor. Pimozide is also a Ca2+ channel antagonist. Pimozide is used as an antipsychotic.
References Liu, J., et al.: Br. J. Pharmacol., 126, 245 (1999); Richelson, E., et al.: Life Sci., 68, 29 (2000); Santi, C., et al.: J. Neurosci., 22, 396 (2002); Mariot, P., et al.: J. Biol. Chem., 277, 10824 (2002); Nikonenko, I., et al.: Mol. Pharmacol., 68, 84 (2005);

• Brand: TRC

Chemical properties

• Molecular weight: 466.58
• Formula: C₂₈H₂₄D₅F₂N₃O
• Color/Form: White To Light Beige
• InChI: InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)/i15D2,16D2,24D
• InChI key: InChIKey=YVUQSNJEYSNKRX-SQXKFXMRSA-N
• SMILES: [2H]C1([2H])CN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC([2H])([2H])C1([2H])n1c(=O)[nH]c2ccccc21