Pixantrone Dimaleate

CAS: 144675-97-8

Ref. TR-P552500

Product Information

• Name: Pixantrone Dimaleate
• Synonyms: Benz[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-, (2Z)-2-butenedioate (1:2), Benz[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-, (Z)-2-butenedioate (1:2), BBR 2778, Pixantrone maleate
• Brand: TRC
• Description: Applications Pixantrone is an antineoplastic drug belonging to group of antitumor antibiotics. Pixantrone is an anlogue of Mitoxantrone (M373425) and is just as potent in the treatment of multiple sclerosis with fewer toxic effects on cardiac tissue. Studies suggest that Pixantrone significantly reduces amyloid beta (A beta(1-42)) neurotoxicity, a mechanism implicated in Alzheimer's disease.References Cavalletti, E. et al.: Invest. New Drugs, 25, 187 (2007); Gonsette, R.E. et al.: J. Neurol. Sci., 223, 81 (2004); Colombo, R. et al.: Electrophoresis, 30, 1418 (2009)

Chemical properties

• Molecular weight: 557.51
• Formula: C₁₇H₁₉N₅O₂·2C₄H₄O₄
• Color/Form: Neat
• InChI: InChI=1S/C17H19N5O2.2C4H4O4/c18-4-7-21-12-1-2-13(22-8-5-19)15-14(12)16(23)10-3-6-20-9-11(10)17(15)24;2*5-3(6)1-2-4(7)8/h1-3,6,9,21-22H,4-5,7-8,18-19H2;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
• InChI key: InChIKey=SVAGFBGXEWPNJC-SPIKMXEPSA-N
• SMILES: NCCNc1ccc(NCCN)c2c1C(=O)c1ccncc1C2=O.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O