Product Information
Name:Plerixafor-d4
Controlled Product
Synonyms:
- 1,1'-[1,4-(Phenylene-d4)bis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane
Brand:TRC
Description:Stability Very HygroscopicApplications Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:506.81
Formula:C28H50D4N8
Color/Form:Off White Solid
InChI:InChI=1S/C28H54N8/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36/h5-8,29-34H,1-4,9-26H2/i5D,6D,7D,8D
InChI key:InChIKey=YIQPUIGJQJDJOS-KDWZCNHSSA-N
SMILES:[2H]c1c([2H])c(CN2CCCNCCNCCCNCC2)c([2H])c([2H])c1CN1CCCNCCNCCCNCC1
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