Plerixafor Hydrochloride (1:8)

CAS: 155148-31-5

Ref. TR-P580505

Product Information

• Name: Plerixafor Hydrochloride (1:8)
• Synonyms: 1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(methylene)]bis-, hydrochloride (1:8), 1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(methylene)]bis-, octahydrochloride (9CI), 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] hydrochloride (1:8), AMD 3100, JM 3100, SID 791, Plerixafor octahydrochloride, 1,1'-(Benzene-1,4-Diyldimethanediyl)Bis-1,4,8,11-Tetraazacyclotetradecane Octahydrochloride Dihydrate, 1,1′-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] hydrochloride (1:8), 1,4,8,11-Tetraazacyclotetradecane, 1,1′-[1,4-phenylenebis(methylene)]bis-, hydrochloride (1:8), 1,4,8,11-Tetraazacyclotetradecane, 1,1′-[1,4-phenylenebis(methylene)]bis-, octahydrochloride, AMD 3100 octahydrochloride, Amd 3100, Jm 3100, Plerixafore 8HCl, Sid 791

Description

Stability Hygroscopic
Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).
References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),

• Brand: TRC

Chemical properties

• Molecular weight: 794.47
• Formula: C₂₈H₅₄N₈ClH
• Color/Form: Neat
• InChI: InChI=1S/C28H54N8.8ClH/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H
• InChI key: InChIKey=YIQPUIGJQJDJOS-UHFFFAOYSA-N
• SMILES: c1cc(CN2CCCNCCNCCCNCC2)ccc1CN1CCCNCCNCCCNCC1