Poly(I:C) (~90%)

CAS: 24939-03-5

Ref. TR-P688075

Product Information

• Name: Poly(I:C) (~90%)
• Synonyms: NSC 120949, NSC 123233, NSC 128576, Poly(C).poly(I), Poly(C:I), Poly(I)-poly(C), Poly(I).poly(C), Poly(cytidylic acid)-poly(inosinic acid), Poly(rI)-poly(rC), Poly(rI).poly(rC), Poly(rI):poly(rC), Poly(rI:rC), Polyinosinate:polycytidylate,5'-Inosinic Acid Homopolymer Complex with 5'-Cytidylic Acid Homopolymer, 5'-Inosinic Acid Polymers Complex with 5'-Cytidylic Acid Polymers, 5'-Cytidylic Acid Homopolymer Complex with 5'-Inosinic Acid Homopolymer, 5'-Cytidylic Acid Polymers Complex with 5'-Inosinic Acid Polymers, 5'-Inosinic Acid Homopolymer-5'-cytidylic Acid Homopolymer Complex, Poly(I).poly(C) Complex, Polycytidylic-polyinosinic Acid, Polyinosinate-polycytidylate Complex, Polyinosine-polycytidylic Acid, Polyinosinic Acid:polycytidylic Acid, Polyinosinic Acid:polycytidylic Acid Complex, Polyinosinic-polycytidylic Acid, Polyinosinic-polycytidylic Acid Complex, Polyribocytidylic Acid-polyriboinosinic Acid Complex, 4-amino-1-(5-O-phosphonopentofuranosyl)pyrimidin-2(1H)-one - 9-(5-O-phosphonopentofuranosyl)-3,9-dihydro-6H-purin-6-one (1:1), 5'-Cytidylic Acid - 5'-Inosinic Acid (1:1), 5′-Cytidylic acid, homopolymer, complex with 5′-inosinic acid homopolymer (1:1), 5′-Cytidylic acid, polymers, complex with 5′-inosinic acid polymers (1:1), 5′-Inosinic acid homopolymer-5′-cytidylic acid homopolymer complex (1:1), 5′-Inosinic acid, homopolymer, complex with 5′-cytidylic acid homopolymer (1:1), 5′-Inosinic acid, polymers, complex with 5′-cytidylic acid polymers (1:1), Poly I:C, Poly I:C Polyinosinicacid-polycytidylic acid, Poly(I).poly(C) complex, Polycytidylic-polyinosinic acid, Polycytidysic acid, Polyinosinate-polycytidylate complex, Polyinosinate:polycytidylate, Polyinosine-polycytidylic acid, Polyinosinic acid-polycytidylic acid, Polyinosinic acid:polycytidylic acid complex, Polyinosinic-polycytidylic acid complex, Polyribocytidylic acid-polyriboinosinic acid complex

Description

Applications Poly(I:C) is a toll-like receptor 3 dsRNA inflammatory stimulant.
References Smith, G.A., et al.: PLoS One, 10, e0121072 (2015); Dauletbaev, N., et al.: J. Immunol., 195, 2829 (2015); Broering, R., et al.: J. Viral Hepatitis, 21, 480 (2014); Colapicchioni, V., et al.: J. Mater. Chem. B: Mater. Biol. Med., 3, 7408 (2015)

• Brand: TRC

Chemical properties

• Molecular weight: 671.40
• Formula: H₂(C₁₀H₁₁N₄O₈P)n·H₂(C₉H₁₂N₃O₈P)n
• Purity: ~90%
• Color/Form: Neat
• InChI: InChI=1S/C10H13N4O8P.C9H14N3O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1
• InChI key: InChIKey=ACEVNMQDUCOKHT-ZLOOHWKQSA-N
• SMILES: Nc1ccn([C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)n1.O=c1nc[nH]c2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O