Pomalidomide-d5

CAS: 19171-19-8

Ref. TR-P688203

Product Information

• Name: Pomalidomide-d5
• Synonyms: (S)-4-Amino-2-(2,6-dioxopiperidin-3-yl-3,4,4,5,5-d5)isoindoline-1,3-dione, 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-, 2-(2,6-Dioxopiperidin-3-yl)-4-amino-isoindole-1,3-dione, 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide, 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione, 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione, 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, 4-Amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione, 4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione, Actimid, Cc 4047, Imnovid, Phthalimide, 3-amino-N-(2,6-dioxo-3-piperidyl)-, Pomalyst

Description

Applications Pomalidomide-d5 is the labeled analogue of Pomalidomide (P688200), a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)

• Brand: TRC

Chemical properties

• Molecular weight: 278.27
• Formula: C₁₃D₅H₆N₃O₄
• Color/Form: Neat
• InChI: InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)/t8-/m0/s1/i4D2,5D2,8D
• InChI key: InChIKey=UVSMNLNDYGZFPF-XHNMXOBISA-N
• SMILES: [2H]C1([2H])C(=O)NC(=O)C([2H])(N2C(=O)c3cccc(N)c3C2=O)C1([2H])[2H]